«ANGIOSCAN-01»:
Professional diagnostic device for assessment of arterial function state.
Price3900 $
​Diagnostic complex AngioScan-01 is represented by hardware and software for PC.​

“AngioScan-01” device is a dual-channel version designed for use in medical institutions by professionally trained medical personnel. Among other AngioScan devices, “AngioScan-01” analyses the widest range of cardiovascular system parameters.

Two channels for photoplethysmography sensors connection are the main distinctive feature of “AngioScan-01”, which makes possible to perform an occlusion test evaluating state of endothelial function. A pharmacological test for assessing the effectiveness of therapy, food supplies, foodstuffs etc. can also be performed.

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Dual-channel clinical version AngioScan device

AngioScan is an innovative technology created for performing a noninvasive examination of heart and vessels by assessing the state of arterial function. The term "arterial function" concerns such parameters as stiffness of arterial wall and state of endothelium. The technology allows one easily and reliably check the heart, and to make early diagnosis of cardiovascular diseases.

Diagnostic complex “AngioScan – 01” is based on recording a pulse wave by an optical sensor operating in the near infrared. The signal received gives a detailed information about the state of stiffness of arterial wall. The occlusion test evaluates the state of endothelial function.

The unique feature of the technology is a contour analysis, performed for analysis of stiffness of arterial wall and simultaneous assessment of vasomotor endothelial function. At the same time the state of the endothelium in small (resistive) and large (conductive) arteries is assessed.

The advantages of a diagnostic system "AngioScan - 01" are the following:

  • Ease of testing;
  • Automatic analysis of the parameters tested;
  • The stiffness of the arterial wall is assessed by evaluating of augmentation index with the visualization of early and late systolic waves;
  • Assessment of endothelial function in small (resistive) and large (conductive) arteries;
  • Evaluation of the central arterial blood pressure.

AngioScan software’ graphical interface provides an operator easy access to all the functionality of the device:

  • Database with personal data of all patients and the test results;
  • Export and import of databases;
  • Charting of trends for all selected test parameters, which allows one to monitor the effectiveness of the therapy;
  • Conducts all types of tests: the contour analysis, occlusion tests, pharmacological tests;
  • Represents the parameters tested on a PC display during the tests;
  • Built-in tools for detailed examination of pulse waves after the test.
Examples of the AngioScan software interface:
“AngioScan-01” is a professional diagnostic device

The developed method is based on monitoring of state of arterial function (stiffness of artery wall and state of endothelial function). Optical sensors operating in the near infrared spectrum and reliably recording pulse wave are used for these purposes.

Hardware component of the device can be presented in a form of a specialized dual-channel photoplethysmography. Herewith we mainly focused on obtaining high-quality source signal while developing the device "Angioskan-01". Through the use of optical sensors with high dynamic range now we can register a permanent component of the signal (DC), associated with a constant optical density of tissue, as well as a variable component of the signal (AC), mainly determined by the activity of the heart (Pic. 1). The bandwidth of the photoplethysmography channel is from 0 to 30Hz. The frequency of digitization of the signal is 1000 Hz, which is determined by the need to measure time intervals with an accuracy of 1 ms. It is especially important when registering (the rate of retardation) a speed delay (phase shift) in the passage of the pulse wave while performing the occlusive test.

Pic. 1. Photoplethysmography signal formation diagram

It should be noted that in reality a scope of the variable component of the signal (АС) is limited to only a few percent of the total optical density.

Picture 2 schematically shows an optical sensor mounted on the terminal phalanx of the finger.

Pic. 2. Schematic representation of an optical sensor mounted on the terminal phalanx of the finger.

Infrared rays passing through the finger are recorded by a photo detector, which converts the light into a voltage (light/voltage converter) or frequency (light/frequency converter).

The signal is recorded either during the passage of photons from the light source to the photo detector through the tissue, or during the reflection, the light is reflected from the tissue back in direction of the photo detector. In the first case, the sensor is installed on the terminal phalanx of the finger, or earlobes, in the second it is installed with an adhesive layer on any part of the skin surface. Sensor operating in mode of light transmission has a better signal / noise ratio and it is more often used in pulse oximetry. Reflective sensor has two main advantages: no restriction on site and minimum compression of the tissue segment. The reflective sensor has significant advantages in cases when the signal is to be monitored during a long period of time (while intensive therapy or observation of a patient), as it is necessary to change the location of sensor, made in a form of “peg”, only after a several hours of test. However, the sensors operating in the mode of light transmission are optimal in case of short-term (few minutes) testing.

Picture 3 shows pulse waves recorded by the optical sensor mounted on the finger.

Pic. 3. Example of typical volume pulse waves.

Assessment of the state of endothelium

Functional (occlusal) and pharmacological tests are used for assessment of the state of endothelial function. While developing the devices we tried to eliminate influence of an operator on test results and to provide an ease of use, so now the devices can be easily used in medical centers, as well as at home.

The registration technology we developed and contour analysis of volume pulse wave make possible to obtain clinically important data about the stiffness of the elastic type arteries (the aorta and its main trunks). Original photoplethysmogram signal processing algorithms assess the following parameters:

  • Duration of the expulsion of blood by the left ventricle;
  • Amplitude and timing of early and late systolic wave;
  • Augmentation index (or effect of the reflected wave);
  • Assessment of the health of baro-receptor sensor system;
  • Value of central arterial blood pressure.

Occlusion test, carried out by using the cuff mounted on the shoulder, registers the state of endothelial function:

  • In small resistive arteries (microcirculation system);
  • In large conductive arteries.

It is possible to evaluate the vasomotor response to exogenous nitric oxide by conducting pharmacological test with nitroglycerin. Respiratory test can identify individuals with severe atherosclerosis of the coronary arteries.

Evaluation of stiffness of the arterial wall

The registration technology we developed and contour analysis of volume pulse wave make possible to obtain clinically important data about the stiffness of the elastic type arteries (the aorta and its main trunks). Original photoplethysmogram signal processing algorithms assess the following parameters:

  • Duration of the expulsion of blood by the left ventricle;
  • Amplitude and timing of early and late systolic wave;
  • Augmentation index (or effect of the reflected wave);
  • Assessment of the health of baro-receptor sensor system.
Assessment of central arterial blood pressure

In recent years it has been found that blood pressure (BP) in the aorta (central blood pressure) reflects the blood flow in the coronary and cerebral vessels, and it is a more reliable predictor of cardiovascular risks rather than blood pressure, traditionally measured at the shoulder. A measurement of blood pressure in the carotid artery can be used for assessing of the central pressure, since it corresponds to a pressure in ascending aorta. The recording of pulse wave in the carotid artery, performed by tonometry sensors, can be used as a direct testing (BP) method followed by measuring of a pulse pressure. The calibration of arterial pulse is based on state of the mean and diastolic (BP) tones, which show constant parameters in different vascular beds.

We have developed an algorithm for evaluation of the central arterial blood pressure. The central arterial blood pressure is assessed by a standard tonometer before the contour analysis.

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AngioScan-01 - Specification
Product Name:
Dual-channel diagnostic device for analysis of cardiovascular system ANGIOSCAN-01
Delivery Set:
Hardware: ANGIOSCAN-01 device, photoplethysmography sensors (2 units), USB cable, PC (optional)
Software: CD-ROM with AngioScan software and USB drivers for PC
Regulating Documents:
Technical Requirements: TU 9442-001-305770000090620-2008
Certificate of Compliance: № ROSS RU.0001.11ИМ25from 27.03.2009
Registration Certificate: FSR № 2008/03976 from 26.12.2008
Specification:
Number of inputs for photoplethysmography sensor connection: 2
Allowable range of operating temperature: +20 .. +40 °C
Allowable range of relative humidity: 20% .. 80%
Power supply: USB port of a PC
Supply voltage: +5 VDC
Power Consumption: < 300 мА
Potential Risk Class: 2a
USB port connector type: USB Type B
Sensor connection type: Redel
Maximum weight (without sensors): 0.5 Kg
Device enclosure size: 102 x 70 x 24 mm
Specification of Analog to Digital Conversion:
Conversion accuracy, bits: 16
Sampling rate: 1000 Hz
Sensor valid output frequency range: 3 .. 120 kHz
PC Hardware requirements:
Type of PC or Laptop: IBM PC compatible
Operating System: Windows XP, Windows Vista, Windows 7 (32 bit only)
Processor Intel P4 and above
RAM: From 1 GB
Display: 1024 x 768, 256 colors
HDD space: 50 Mb
Drive: CD-ROM
USB port: USB Port Type A
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WHERE ARE WE LOCATED

OUR CONTACTS

  • Active Air LTD
  • Address: 20 building 3, Elekrozavodskaya street, Moscow
  • Registration certificate: series 77 #013249592
    Personal tax reference number: 7718796335
    Basic State Registration Number: 1107746118810
  • Invoice account:40702810830170959801 at Bank VTB 24
    BIK (sort code): 044525555
    Account: 30101810400000000555
    Phone number: +7 (495) 120-60-60
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